ISDIN Isdinceutics Retinal Advanced Night Serum
ISDINCEUTICS® Retinal Advanced
A dual-phase night serum built to give retinoid results without the usual irritation trade-off.
This night serum separates its rejuvenating oil phase from its soothing aqueous phase in the packaging, combining them only at the moment of application to preserve the stability and effectiveness of both. Retinaldehyde, closer in activity to prescription-strength retinoic acid than standard retinol, supports collagen production and skin renewal, working alongside melatonin's antioxidant defense against free radicals and bakuchiol's retinol-like elasticity support. A Soothing Complex built around niacinamide hydrates and calms as the actives work, minimizing the dryness and sensitivity retinoids are known for. Non-comedogenic, mineral oil-free, and suitable for all skin types, including sensitive skin.
Why it works: Retinoids are effective at reducing wrinkles precisely because they're potent, which is also what makes them irritating for many people, often to the point they stop using them before seeing results. Combining the active phase with a dedicated soothing phase, mixed fresh at each application, means the serum can use a genuinely potent retinaldehyde without the compromise of built-in irritation. In clinical testing, wrinkles decreased 43% after 4 weeks, with 97% of users noting a reduction in fine lines and 97% reporting no discomfort.
How to use it:
- Press the pump twice and mix the two phases in your palm.
- Apply to clean, dry skin at night, avoiding the eye area.
- Ease in gradually: three nights a week initially, increasing toward daily use over three weeks.
- Follow every morning with a broad spectrum sunscreen.
The worth//vitality promise
We chose this serum because it solves the real reason most people abandon retinoids: irritation before results ever show up. Ninety-seven percent of users reporting no discomfort alongside a 43% reduction in wrinkles is a rare combination, and it's exactly the kind of result that earns a night serum its place in the lineup: real potency, without the trade-off.